The Cadillac DeVille was originally a trim level of the Cadillac Series 62 and later a separate model when the Series designation was dropped by Cadillac. The first car to bear the name was the 1949 Coupe de Ville, a pillarless two-door hardtop body style with a prestige trim level above that of the Series 62 luxury coupe. The last model to be formally known as a DeVille was the 2005 Cadillac DeVille, a full-size sedan, the largest car in the Cadillac model range at the time. The next year, the DeVille was officially renamed the Cadillac DTS.

Cadillac was restyled and re-engineered for 1961. The new grille slanted back towards both the bumper and the hood lip, along the horizontal plane, and sat between dual headlamps. New forward slanting front pillars with non-wraparound windshield glass were seen. The revised backlight treatment had crisp angular lines with thin pillars on some models and heavier semi-blind quarter roof posts on others. DeVille models featured front series designation scripts and lower body "skeg fins" trimmed with a thin, three-quarter-length spear molding running from behind the front wheel opening to the rear of the car. Standard equipment included power brakes, power steering, automatic transmission, dual backup lights, windshield washer, dual speed wipers, wheel discs, plain fender skirts, outside rearview mirror, vanity mirror, oil filter, power windows and 2-way power seats. Rubberized front and rear coil springs replaced the trouble prone air suspension system. Four-barrel induction systems were now the sole power choice and dual exhausts were no longer available. A new short-decked four-door Town Sedan hardtop appeared mid-season.